Evidence for Resident Memory T cells in Rasmussen Encephalitis
نویسندگان
چکیده
Investigators from University of California Los Angeles studied the presence of different T cell subset population in the brain tissue of 7 patients with Rasmussen encephalitis, a rare neuroinflammatory disorder characterized by intractable seizures and usually associated with progressive hemi cerebral atrophy, who underwent brain surgery and compared them to patients with focal cortical dysplasia.
منابع مشابه
Evidence for Resident Memory T Cells in Rasmussen Encephalitis
Rasmussen encephalitis (RE) is a rare pediatric neuroinflammatory disease of unknown etiology characterized by intractable seizures, and progressive atrophy usually confined to one cerebral hemisphere. Surgical removal or disconnection of the affected cerebral hemisphere is currently the only intervention that effectively stops the seizures. Histopathological evaluation of resected brain tissue...
متن کاملMaintenance of PD-1 on brain-resident memory CD8 T cells is antigen-independent
Infection of the central nervous system (CNS) by murine polyomavirus (MuPyV), a persistent natural mouse pathogen, establishes brain-resident memory CD8 T cells (bTRM) that uniformly and chronically express programmed cell death protein 1 (PD-1) irrespective of the expression of αE integrin CD103, a TRM cell marker. In contrast, memory antiviral CD8 T cells in the spleen are PD-1-, despite vira...
متن کاملThe Emerging Role of Gamma-Delta (γδ) T cells in Neurological Diseases and Rasmussen Encephalitis
Submit Manuscript | http://medcraveonline.com Abbreviations: TCR: γδT Receptor; RE: Rasmussen’s Encephalitis; CD: Cortical Dysplasia; APCs: Antigen Presenting Cells; MS: Multiple Sclerosis; BBB: Blood Brian Barrier; GBM: Glioblastoma Multiforme; MGMT: Methylguanine Methyltransferase; NK: Natural Killer; WNV: West Nile virus RR: Relapsing Remitting; PP: Primary Progressive; SP: Secondary Progres...
متن کاملPhenotypic and functional complexity of brain-infiltrating T cells in Rasmussen encephalitis
Objective To characterize the brain-infiltrating immune cell repertoire in Rasmussen encephalitis (RE) with special focus on the subsets, clonality, and their cytokine profile. Methods The immune cell infiltrate of freshly isolated brain tissue from RE was phenotypically and functionally characterized using immunohistology, flow cytometry, and T-cell receptor (TCR) deep sequencing. Identifica...
متن کاملO 18: Autoimmune Dementia
Dementia is defined as significant acquired cognitive impairment in one or more cognitive domains that represents a significant decline from previous baseline and interferes with independence in daily activities. Autoimmune dementia is a term that has been used to describe a steroid-responsive autoimmune disorder characterized by a rapidly progressive dementia with a fluctuating course. Even co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 30 شماره
صفحات -
تاریخ انتشار 2016